Dupuytren’s Disease

What is Dupuytren's Disease?

Dupuytren’s disease is a condition where the connective tissue in the palm and fingers thickens and tightens, causing the fingers to bend towards the palm. This usually painless thickening can make it increasingly difficult to fully extend the fingers. The most affected fingers are the ring and little fingers, which may bend significantly in severe cases. Dupuytren’s disease is more common in Caucasians, particularly those of Northern European descent, and is more prevalent in men.

Dupuytren’s disease is not categorized into distinct “types,” but it presents with varying degrees of severity:

  1. Early Stage: Small nodules may form in the palm. These nodules are usually painless but can be indicative of the disease’s onset.
  2. Intermediate Stage: Nodules develop into thick cords that extend from the palm into the fingers, causing the fingers to bend inward.
  3. Advanced Stage: In severe cases, the fingers are significantly bent towards the palm. This stage can severely impact daily functions, such as grasping objects or performing tasks that require full finger extension.

The exact cause of Dupuytren’s disease remains unknown, but it is strongly associated with genetic factors. The condition tends to run in families, particularly among individuals of Northern European descent. There is no definitive evidence linking the condition to injuries or excessive hand use, it is generally not considered to be caused by trauma or repetitive strain. Some people may have a “Dupuytren’s Diathesis” and have similar thickenings of fibrous tissue in their feet (Lederhosen’s disease) and genitals (Peyronie’s Disease).

Symptoms develop gradually and include:

  • Nodules in the Palm: Small, firm lumps in the palm that may sometimes be painful.
  • Thickened Cords: As the disease progresses, these nodules form thick cords of tissue that extend into the fingers, causing them to curl towards the palm.
  • Loss of Finger Extension: Difficulty in fully extending the fingers, which can be tested using the “table top test” where the hand cannot lie flat on a surface.
  • Functional Impairments: Problems with performing everyday tasks, such as getting hands into pockets or washing the face, due to the limited range of motion.

Anatomy

Understanding Dupuytren’s Disease involves knowing a bit about hand anatomy. The palmar fascia is the connective tissue in the palm that thickens in this condition. This tissue is located just beneath the skin and above the tendons that help move the fingers. In Dupuytren’s Disease, this tissue becomes abnormally thick and fibrous, forming nodules and cords that restrict finger movement. The flexor tendons are responsible for bending the fingers, but when the fibrous cords contract, they pull the fingers inward, reducing their range of motion. As the condition progresses, it can significantly affect the function of the fingers and hand.

Treatment & Surgery Options

In the early stages of Dupuytren’s disease or when symptoms are mild, non-surgical treatments may be appropriate:

  1. Steroid Injections: For painful lumps or nodules, a steroid injection can help reduce inflammation and discomfort. This treatment is usually low-risk but may have variable effectiveness.
  2. Collagenase Injections: A more recent treatment involves injecting an enzyme called collagenase into the thickened cords. This enzyme breaks down the collagen, allowing for the correction of finger deformities without surgery. This method often leads to quicker recovery compared to traditional surgical methods. It is currently not available in Australia.

Surgery is considered when Dupuytren’s disease significantly impacts hand function or when the contracture becomes severe. Surgical guidelines consider intervention when there is a 30-degree contracture of the MCP joint or any contracture of the PIP joint. Functional difficulties are the main reason for opting for surgery.

  1. Fasciotomy: This procedure involves making an incision to cut and remove the thickened cords of tissue. This helps restore the ability to extend the fingers.
  2. Fasciectomy: For more severe cases, the affected palmar fascia may be removed entirely. Skin grafting might be required to cover the wound and promote healing.
  3. Skin Grafting: In cases where a significant amount of tissue is removed, skin grafts may be necessary to cover the area and aid in recovery.

Recurrence

Recurrence of Dupuytren’s disease is common, but it may not always be clinically significant. Even after successful treatment, the condition can return. This is more common in younger patients, females, Dupuytren’s diathesis and those with more significant disease. In some cases, additional surgery may be required if the disease progresses or recurs.

Post-operative recovery from Dupuytren’s surgery typically includes:

  • Initial Dressing: After surgery, the hand is placed in a bulky dressing for approximately 2 weeks to support the new finger positions.
  • Removable Splint: Following the initial period, a removable splint is used for an additional 4 weeks at night. During this time, patients start range of motion exercises to regain finger movement and flexibility.
  • Overall Recovery: Full recovery generally takes 2 to 3 months. Patients will engage in hand therapy to improve function and strength.

Downloadable info sheets related to Dupuytren’s Disease

These notes have been prepared by orthopaedic surgeons at OrthoSport Victoria. They are a general overview and reflect their views, opinions and recommendations. The contents are provided for information and education purposes only and not for the purpose of rendering medical advice. Please seek the advice of your surgeon or other health care provider with any questions regarding medical conditions and treatment.

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